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Lead compounds in drug discovery are compounds with pharmacological or biological activities and potential therapeutic uses selected from a series of hits by refining the screening criteria. The discovery and selection of lead compounds occurs before the preclinical and clinical development of drug candidates and it is the foundation of new drug research and development. The most promising compounds are selected and used for further development.
Lead compounds may have sub-optimal structures, so modification is required to improve their potency, selectivity, pharmacokinetic parameters or druglikeness as well as to reduce off-target activities to fit better to the target and become drug-like enough for biological or clinically testing. Lead optimization is based on physiochemical/metabolic properties suggestive of reasonable in vivo pharmacokinetics and structure-activity relationship (SAR) as well as animal efficacy models and ADMET tools. Lead optimization aims to convert lead compounds into candidates for preclinical evaluation.
The foundation of the pharmaceutical industry is the ability to successfully screen drug candidates. On average, only one of the 5,000 compounds may enter the preclinical development stage from the drug discovery stage, and become an approved drug according to statistics. Thus the real issue now is not the shortage of drug target of how many new compounds can be found, but how many new compounds can be identified as potential therapeutic candidates for future development. Increasing emphasis is being placed on lead validation.
Creative Biolabs provides powerful risk-based preclinical data verification services for lead validation of drug discovery process to deal with data reproducibility crisis which is a big obstacle for drug research and development and may lead to failure and high risk of investment. Lead validation can help make the candidate decision more efficient and improve the success rate of our clients’ projects.
Creative Biolabs provides developability assessment of lead compounds to evaluate the drug-like properties of potential therapeutic candidates and to select the candidate with the most stable profile. This can minimize the risks of costly late-stage failures for industry. We provide comprehensive and state-of-the-art CreDA™ developability assessment services to help our clients address the issues that may lead to potential clinical failure.
Creative Biolabs provides a wide variety of in vitro and in vivo pharmacology studies. Pharmacology is a branch of biology which studies drug actions at all levels and can provide important information for preclinical and clinical studies. The two main areas of pharmacology are pharmacodynamics and pharmacokinetics. Pharmacology studies are of great importance in determining the effect of lead compound during drug discovery and can provide key evidence for lead optimization and the selection of drug candidates for further development.
Toxicology mainly studies the harmful effects of exogenous factors on biological systems. Drug-induced toxicity is the key reason for drug failure in the discovery process. It is essential to evaluate the toxicology potential of drug candidates at an early stage to save time and resource investment. Creative Biolabs is an ideal partner offering toxicology studies for the assessment of lead compounds to help our clients understand the toxic liability of your compounds.
Pathology is a significant branch of medical science and a major field in modern medicine and diagnosis. The task of pathology is to use various methods to study the causes of disease, the pathogenesis and the pathological changes of organism including the changes of function, metabolism and morphology. Pathology plays a critical role in safety assessment of lead compounds as potential drug candidates. Creative Biolabs can provide a wide array of routine and specialized pathology services to help our clients in pathology research and further drug discovery.
In addition, Creative Biolabs has a dedicated assay development team that will work closely with you to design customized assays. We are confident to offer the most appropriate strategies based on a broad variety of cell lines and animal models to assist our clients in selecting the most appropriate candidate for their project at an early stage.
Our service will meet your specific needs fast at extremely competitive prices. We will be with you at every step of your way. For more detailed information, please feel free to contact us or directly sent us an inquiry. We look forward to working with you.