Pathology Studies

Pathology is a significant branch of medical science and a major field in modern medicine and diagnosis. The task of pathology is to use various methods to study the causes of disease, the pathogenesis and the pathological changes of organism including the changes of function, metabolism and morphology. Pathology can provide the necessary theoretical basis for understanding the occurrence and development of diseases. To determine the safety, efficacy and mechanism of action of potential therapeutic agents, a comprehensive assessment of pathological changes is indispensable. Pathology plays a critical role in safety assessment of lead compounds as potential drug candidates.

Pathology Studies

Creative Biolabs provides professional pathology studies for lead validation of drug discovery process thus to deal with data reproducibility crisis which is a big obstacle for drug research and development and may lead to failure and high risk of investment. Our extensive pathological services can be used to support in vivo studies performed in vitro or as an independent service. With our professional pathology studies and various animal models, we can drive forward and speed up your drug discovery process.

Creative Biolabs offers comprehensive pathology studies, including but not limited to the following:

Anatomic Pathology

Anatomic pathology or anatomical pathology, one of two main divisions of the medical practice of pathology, studies the influence of disease on the structure of body organs and tissues from macro and micro perspectives by using a microscope, or through molecular, biochemical or immunological means. The main role of anatomic pathology is to identify abnormal pathological morphology that can help to diagnose disease and manage treatment. Our preclinical anatomic pathology services can evaluate the potential toxicity and risks of leads and drug candidates.

Clinical Pathology

Clinical pathology, also known as laboratory medicine, is the other one of two main divisions of the medical practice of pathology. It uses chemical, microbiological, hematological and molecular pathological tools to diagnose diseases through laboratory analysis of body fluids, such as blood, urine and tissue homogenates or extracts. We provide a complete spectrum of clinical pathology laboratory services to support all stages of drug research and development including animal research, safety assessment and preclinical studies. Our services are applied for experimental animals by contributing comprehensive data and its interpretation based on multiple species, study design, test item class and mode of action, as well as mechanisms of toxicity.

Molecular Pathology

Molecular pathology is focused on the study and diagnosis of disease through the examination of molecules within organs, tissues or bodily fluids and is commonly used in diagnosis of cancer and infectious diseases. Molecular pathology is a natural extension of anatomic and clinical pathology. Quantitative polymerase chain reaction (qPCR), DNA microarray, DNA sequencing, in situ hybridization and other numerous techniques based on the analysis of DNA and RNA samples have been applied in molecular pathology.

Neuropathology

Neuropathology refers to the study of disease of nervous system tissue. The examination of a biopsy of nervous tissue took from the brain, spinal cord and peripheral nerve system can aid in diagnosis of disease. Neuropathology can be used to detect whether the novel therapies have potential damage to the brain and neuro system. In addition, it is a powerful tool to examine the efficacy of the candidate neurological drugs. We have a professional team consisted of neuroscientists and neuropathologists who have particular diagnostic and research expertise in brain and neurological disorders to provide high-quality pathological services in the specialized area of neuropathology.

Developmental & Reproductive Pathology

Developmental and reproductive pathology mainly evaluates the effects of potential therapeutic agents on reproductive function and development of offspring. It focuses on studying the factors interfering normal reproduction and development, as well as what changes are caused by the factors. Many drugs have been proven harmful to human reproductive system. So it is necessary to evaluate potential effects of candidates on reproductive function and development of offspring. We can provide pathology support for assessing development and reproductive toxicology by our pathologists who have years of experience in evaluating potential effects of potential drug candidates in animals of different ages and stages.

Creative Biolabs has a dedicated assay development team that will work closely with you to design customized assays. Our service will meet your specific needs fast at extremely competitive prices. If you need more information, please feel free to contact us at anytime. We look forward to working with you to help your drug research and development project succeed.

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