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With in-person events back again, Creative Biolabs is excited to greet you at the upcoming international conferences. Meet our team at 2022 BIO International Convention in June (booth #1754) and at the 13th Annual World ADC San Diego in September (booth number to be updated) for expert consultation on your drug discovery. Shoot an email to arrange an in-person meeting!

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Protein Drugs

Proteins are macromolecules which made up of one or more polypeptides arranged in a biologically functional way. Protein is the executor of gene function. Proteins often bind to ligands such as coenzymes and cofactors, or to another proteins or other macromolecules such as DNA and RNA, or to complex macromolecular assemblies. Proteins are involved in every function in the living cells and possess a range of physiological functions, and protein-protein interaction is the basis of organism's life activities.

Protein drugs are protein products with certain biological activities for the prevention and diagnosis of diseases. They can be derived from plants and animals, or developed through biotechnology research. Protein drugs in a broad sense include all products whose chemical nature is protein or polypeptide, such as hormones, growth factors/cytokines, plasma proteins, enzymes, coagulation factors, antibodies, protein vaccines, etc.

Protein drugs are characterized by high activity, high specificity, low toxicity, clear biological function and good clinical application. They have become an important part of pharmaceutical products because of its low cost, high success rate, safety and reliability. However, there are also several obstacles in the development of protein drugs such as complex structure, short half-life, instability in vivo and in vitro, and high molecular weight.

Complexity of therapeutic protein drugsFigure 1. Complexity of therapeutic protein drugs. (Lagassé, H. A. D., et al., 2017)

Protein drugs are the most active and fast-growing part in the field of drug research and development, and one of the most promising industries in the twenty-first century. Therapeutic protein drugs are important for patients who need novel therapies. Protein drugs are developed to treat a wide variety of clinical indications, including cancers, autoimmune diseases, inflammation, diabetes neurodegenerative effects, exposure to infectious agents, and genetic disorders. Recent approved recombinant protein therapeutics ha been used to target specific sites.

Creative Biolabs provides powerful risk-based preclinical data verification services for protein drug research and development to deal with data reproducibility crisis which is a big obstacle for drug research and development and may lead to failure and high risk of investment. We have extensive experience in different kinds of protein drugs and different disease areas with a focus on target validation, hit validation, lead validation, safety assessment and efficacy evaluation.

Creative Biolabs can provide customized services for your project to meet your specific needs in a timely and cost-effective manner. Our project feasibility assessment services will help you make wise decision thus to reduce investment risk. With professional scientific team and state-of-the-art technology, we are confident to give our clients high-quality and reliable results. Given our professional in drug discovery and development, you’ll benefit from our full-service lab capabilities.

As a global contract research organization with advanced equipment, Creative Biolabs convinces out clients that they will receive fully compliant and trustworthy results at promised time. We are an ideal partner for you to help you reduce investment risk and accelerate your project process.

If you are interested in our services or have any questions, please feel free to contact us at any time. We are sincerely looking forward to cooperating with you.

Reference

  1. Lagassé, H. A. D., et al., 2017. Recent advances in (therapeutic protein) drug development. F1000Research, 6.

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