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With in-person events back again, Creative Biolabs is excited to greet you at the upcoming international conferences. Meet our team at 2022 BIO International Convention in June (booth #1754) and at the 13th Annual World ADC San Diego in September (booth number to be updated) for expert consultation on your drug discovery. Shoot an email to arrange an in-person meeting!

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Virotherapy Development

Virotherapy is an emerging branch of therapies that explores viruses to defeat diverse types of diseases, including congenital genetic, infectious, cardiovascular and autoimmune diseases, especially cancers. Significant improvements in vector engineering, delivery, and safety have placed virotherapy at the forefront of modern medicine. So, it is important and necessary to perform preclinical data verification and project feasibility assessment in the development of a virotherapy project. As a leading CRO company with decades of industry experience, Creative Biolabs provides comprehensive preclinical & clinical assessment services to help reduce investment risk and accelerate the process of your project.

Mechanisms of Virotherapy

Generally, virotherapy works through three different pathways: gene overexpression, gene knockout, and suicide gene delivery.

The rationale of virotherapy.Fig.1 The rationale of virotherapy.

Classification of Virotherapy

Oncolytic Virus Development

Oncolytic virotherapy is a therapeutic approach that utilizes native or genetically modified oncolytic viruses (OVs) to treat cancers. OVs promote anti-tumor responses through a dual mechanism of action: Directly by infecting and killing tumor cells and indirectly by stimulating a therapeutically relevant tumor-targeting immune response. OVs encompasses a broad diversity of DNA and RNA viruses with improved specificity and potency. Various OVs have been developed, including oncolytic measles virus, oncolytic vaccinia viruses, oncolytic HSV, reovirus and so on.

Applications of viral vectors have found an encouraging beginning in gene therapy due to virus tropism. Actually, particular viruses have been selected as gene delivery vehicles to carry foreign genes to specific tissues or cells to provide either transient or permanent transgene expression. The spectrum of viral vectors is very broad, including adenoviruses (Ads), retroviruses (γ-retroviruses and lentiviruses (LV)), poxviruses, adeno-associated viruses (AAVs), and herpes simplex viruses (HSV), etc. The choice of virus for clinical use depends on the efficiency of transgene expression, vector capacity, ease of production, safety, toxicity, and stability.

Viral Vector Development
Viral Immunotherapy Development

Viral immunotherapy utilizes genetically engineered viruses to present a specific antigen or immune modulator to the immune system to enhance the anti-tumor inflammatory response. The antigen may be derived from any species of virus/bacteria, or even cellular proteins released from the OV-lysed tumor cells, known as damage-associated molecular patterns and tumor-associated antigens (TAAs). These TAAs activate dendritic cells and elicit adaptive antitumor immunity.

Benefits of Virotherapy

Based on the outstanding expertise and rich experience, Creative Biolabs is dedicated to providing professional drug development consulting services in various disease areas with different drug modalities to navigate the pharmaceutical industry for our clients. Our powerful risk-based consulting platform focus on project assessment, preclinical and clinical drug development. We serve our clients with the most reliable and qualified results to help make informed decisions thus reducing investment risk. Please contact us and learn more by sending an E-mail and our team will get back to you as soon as possible. We look forward to working with you and we will be your best partner.

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