Small Molecule Drug Development
Small molecule drugs
are chemically synthesized active organic compounds with a low molecular weight
usually less than 900 daltons which can be made into tablets or capsules that
are easily absorbed. As traditional form of medicine, small molecule drugs have
always been an important part of drug research and have irreplaceable places.
Up to now, small molecule drugs involved in therapeutic use can be divided into
small molecule inhibitors, small molecule antagonists, small molecule agonists
and small molecule activators. They are also valuable tools of biological
The drug development
process of small molecule drugs include initial target identification and
validation, assay development and model establishment for in vitro and in vivo screening and optimization of lead compounds, the relationship between
pharmacokinetic characteristics and targets, preclinical safety assessment, preclinical
candidate selection and clinical research. The
development of effective small molecule drugs requires a strong cooperative
relationship between biologists and chemists. An in-depth understanding of the target
is essential for the generation and optimization of compounds with the most
beneficial efficacy and safety characteristics. At the same time, chemical
knowledge must be acquired to ensure new, selective and high-quality candidates
Most of the lead
compounds eliminated in the
later stage of research and development have problems with
unsatisfactory efficacy or too much side effects, or have no obvious advantages and improvements compared with
the listed drugs. These complex steps and potential problems make the entire drug development
process extremely long and full of risks of failure and investment.
Therefore, it is very essential to establish a rapid and
effective early comprehensive evaluation system to verify the potential safety
and possible clinical effectiveness of drug target and biologically active lead
compounds. Quick and scientific decisions of new drug development can be made based
on these verification data to save time and minimize the risk.
Creative Biolabs provides risk-based preclinical data verification services for small molecule drug research and
development projects. We have extensive experience in different kinds of small
molecule drugs and different disease areas with a focus on target validation, hit validation, lead
validation, safety assessment and efficacy evaluation.
As a global contract research organization with advanced equipment
and up-to-date technology, Creative
Biolabs’ professional scientific team involving biologists, chemists, and
pharmacologists can make sure
that our clients will receive fully compliant and trustworthy results in the
timelines promised. We can help our clients verify the safety and efficacy of compounds
to discover a quality drug candidate.
Biolabs can offer
customized and most suitable methods to meet your specific needs in a
cost-effective manner. We are
confident to offer our clients with Project Feasibility Assessment through a comprehensive assessment of you drug candidates
to help reduce investment risk.
Our services will be of great benefit to you for
your drugs research and development projects. If you are interested in our services or
have any other questions, please feel free to contact us. We are always there for you and we look
forward to working with you in the near future.
Explore our detailed services for each type of small molecule
Small Molecule Inhibitors
Small Molecule Antagonists
Small Molecule Activators