Efficacy Evaluation

Drug efficacy refers to the ability of a drug to provide beneficial effects. The evaluation of drug efficacy is the critical factor to decide whether a drug can finally be marketed after ensuring its safety. Drug efficacy evaluation includes studies in animal trials and human clinical trials. For drug research and development, animal pharmacodynamic studies are the basis of human clinical trials. A drug candidate must have certain results of animal studies before human trials, which is in accordance with the principles of ethics. Pharmacodynamic effects and pharmacokinetic characteristics should be included in the evaluation of the drug efficacy in animals, with the aim of ensuring the effectiveness of drug candidates for the first time used in humans. Drugs can finally be marketed and widely used only after human clinical trials prove the safety and effectiveness of drugs.

Pharmacodynamics (PD) refers to the biological response of human body to drugs, which is described by biochemical or molecular interactions. The main pharmacodynamic effects of drugs are reflected by appropriate in vitro and in vivo models according to the classification and pharmacological characteristics of drugs. Pharmacokinetics (PK) refers to the movement of drugs through the body. The purpose of preclinical pharmacokinetic studies is to reveal the dynamic changes of new drugs in animals, and to elucidate the processes and characteristics of drug absorption, distribution, metabolism and excretion (ADME) which are closely related to the actual efficacy of drugs. The significance of preclinical pharmacokinetic studies is to explain the results of pharmacodynamic studies and to suggest information about the possibility of drug interactions. Therefore, preclinical pharmacokinetic studies should be closely combined with pharmacodynamic studies to provide evidence for the drug efficacy. These can provide basis for the development of new drugs and effective support for clinical research.

Creative Biolabs provides powerful risk-based preclinical data verification services for drug research and development to deal with data reproducibility crisis which is a big obstacle for drug research and development and may lead to failure and high risk of investment. Our scientific and regulatory staff work with clients to develop and execute individual studies or customized testing programs to ensure that drug efficacy evaluation is conducted in the most efficient manner.

Pharmacodynamics (PD)

Pharmacodynamics

Creative Biolabs provides pharmacodynamic studies to quantify the characterization of the intensity of effects resulting from certain drug concentrations at the hypothetical effect site in order to determine whether the drug candidate is effective or not. Pharmacodynamic studies can be performed either at cellular level or in animal models. A variety of cell-based services and different animal models including various kinds of disease models are available at Creative Biolabs. This enables us to provide pharmacodynamic services to various kinds of drugs for multiple diseases. And our services can meet your different needs.

Pharmacokinetics (PK)

Pharmacokinetics

Creative Biolabs provides pharmacokinetic studies to reveal the dynamic changes of new drugs in animals, and to elucidate the processes and characteristics of drug absorption, distribution, metabolism and excretion (ADME), which are closely related to the actual efficacy of drugs. PK studies should be closely combined with PD studies to provide evidence for the drug efficacy. We conduct experiments using multiple advanced technologies and analysis systems to satisfy different demands of PK studies.

PK/PD Analysis

PK/PD Analysis

Creative Biolabs is specialized in conducting PK/PD analysis either in normal animal models or disease models for drug discovery and development. We offer either model dependent or independent analysis services to evaluate the PK/PD of your drug candidates. We can perform bioanalytical analysis quickly to validate the sensitive and accurate of PK/PD assays in a number of different matrices from different species. Our analysis information will provide you with valuable insights into the design of preclinical and clinical studies.

Creative Biolabs has expertise in designing and performing drug efficacy evaluation studies. Based on our experienced teams with deep understanding of drug research, we can tailor the experiment plan for your specific needs. Our risk-based preclinical data verification services will help you reduce investment risk and facilitate your research on drug discovery and development. We will be your best partner with high quality and rapid turnaround services. Please feel free to contact us at any time.

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