Toxicology Studies

The field of toxicology overlaps with biology, chemistry, pharmacology, and medicine. Toxicology mainly studies the harmful effects of exogenous factors (chemical, physical and biological factors) on biological systems, and the toxicity can be evaluated qualitatively and quantitatively.

Drug-induced toxicity is the key reason for drug failure in the drug discovery process. It is necessary to assess the potential toxicity of lead compounds and new drug candidates through toxicological studies. Pharmaceutical products must undergo a battery of preclinical toxicology studies to provide information regarding the safety of a new drug candidate. Toxicology studies are generally required by regulatory agencies worldwide before initiating clinical trials in humans and obtaining the market approval of the drug. To save time and resources, it is important to evaluate toxicology potential of drug candidates at an early stage.

Creative Biolabs provides professional toxicology studies for lead validation of drug discovery process thus to deal with data reproducibility crisis which is a big obstacle for drug research and development and may lead to failure and high risk of investment. With our professional toxicology studies, we can drive forward and speed up your drug discovery process.

Creative Biolabs offers comprehensive toxicology studies, including but not limited to the following:

Toxicokinetics

Toxicokinetics (TK) is the use of pharmacokinetics and toxicology to study the occurrence and development of toxicity or adverse effects of exogenous substances. It studies the effect of the human body on drugs when given a higher dose relative to the therapeutic dose. By performing TK studies, findings of toxicity can be correlated with corresponding levels of drug exposure. As an important step in drug discovery and development process, the data obtained from TK study is of great value in the selection of dose, dosing form, alternative dosing route, and evaluation of toxicological mechanism. Creative Biolabs is able to perform toxicology studies in a wide range of species, including but not limited to mice, rats, rabbits, and non-human primates. With years of experience in TK studies, we can provide a variety of administration routes, types of toxicity studies, and complex nonclinical study designs that meet your needs.

In Vitro Toxicology

In vitro toxicology is employed primarily to study the toxic properties in the early stages of the development of potentially useful new substances such as therapeutic drugs. The use of in vitro systems such as cells and tissues can facilitate understanding of toxicant activities and better define human-specific toxic effects. The development of cost-effective assays and highly accurate in vitro practices is becoming increasingly important. Creative Biolabs specializes in using a variety of in vitro toxicity assays to determine potential toxicity to different tissues and organs. We are an ideal partner to test the potential toxicities of lead compounds and candidate drug compounds.

In Vivo Toxicology

In vivo toxicology is based on quantitative and statistical analysis to study the toxic effects of chemical and biological substances within living organisms, such as laboratory animals. Creative Biolabs provides comprehensive in vivo toxicity services to support our global clients’ pharmaceutical R&D projects. We have established a toxicology department consisting of a team of professionals with extensive experience in toxicology studies to help our clients identify potential risk factors in the early stages of their drug discovery and development projects.

Creative Biolabs has a dedicated assay development team that will work closely with you to design customized assays. Our service will meet your specific needs fast at extremely competitive prices. If you need more information, please feel free to contact us at anytime. We look forward to working with you to help your drug research and development project succeed.