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Nucleic acids, including DNA and RNA, are macromolecules that store genetic information and enable protein production. These molecules, which are composed of long strands of nucleotides, are the most important molecules of all biomolecules and essential to all known forms of life. Nucleic acids are an important class of drug targets especially in gene therapy. They have particular significance in the medicinal chemistry of certain anticancer drugs.
Figure 1. Nucleic acid-based therapeutic strategies. (Madhuri, C., et al., 2017)
Creative Biolabs provides a comprehensive target validation services to help confirm various types of nucleic acids as therapeutic targets of drug discovery process thus to deal with data reproducibility crisis which is a big obstacle for drug research and development and may lead to failure and high risk of investment.
Creative Biolabs provides a comprehensive list of assays on multiple high-quality platforms to characterize the features of different nucleic acids as your drug targets to advance your drug discovery. With experienced experts and cutting-edge technologies, we can provide high-quality and reliable services in a time-saving and cost-efficient manner. We offer professional target validation services for the following types of nucleic acids.
DNA
DNA, abbreviation of deoxyribonucleic acid, is a complex molecule with double-helix structure formed by base pairs attached to a sugar-phosphate backbone. An important property of DNA is that it can replicate. DNA contains all the information necessary for the development, function, growth, reproduction and maintenance of all known organisms and many viruses. It also serves as the primary unit of heredity in organisms.
DNA is a key target for drugs because it interferes with genes expression and protein production. In addition, the process of DNA replication can also be affected, which is important for cell growth and the ability of cells to divide successfully. DNA has been used as targets for anti-cancer drugs. The increasing knowledge of DNA and its role in the human body can hopefully provide more successful treatments that target various diseases.
RNA
RNA, abbreviation of ribonucleic acid, is a complex molecule assembled as a chain of nucleotides and mainly functions in cellular protein synthesis. RNA plays an essential biological role in coding, decoding, regulation and expression of genes. From cell division, differentiation and growth to cell aging and death, RNA also plays an important role in catalysis, protein function and transport, peptide bond formation and RNA splicing. Messenger RNA (mRNA), transfer RNA (tRNA) and ribosomal RNA (rRNA) are the three most well-known and most commonly studied RNA involved in protein synthesis.
Defects in certain RNAs or the regulation of RNAs have been implicated in a number of important human diseases, including heart disease, some cancers, stroke and many others. The recent advancement in sequencing and other technologies, as well as knowledge of RNA-related diversity, structural and functional information has put it in the limelight as a drug target. New research has found that RNA is a potential target in a multitude of diseases, including cancer and bacterial/viral infections.
Creative Biolabs has a dedicated assay development team that will work closely with you to design customized assays for your specific drug target. Our service will meet your specific needs fast at extremely competitive prices. If you need more information, please feel free to contact us at anytime. We look forward to working with you and helping your drug research and development project succeed.
