Pharmacokinetics (PK)

Pharmacokinetics (PK) refers to the movement of drugs through the body. The purpose of preclinical pharmacokinetic studies is to reveal the dynamic changes of new drugs in animals, and to elucidate the processes and characteristics of drug absorption, distribution, metabolism and excretion (ADME), which are closely related to the actual efficacy of drugs. In short, PK is to discover how an organism affects a drug. The significance of preclinical pharmacokinetic studies is to explain the results of pharmacodynamic studies and to suggest information about the possibility of drug interactions. Therefore, preclinical pharmacokinetic studies should be closely combined with pharmacodynamic studies to provide evidence for the drug efficacy.

Figure 1. Pharmacokinetics of drugs in heart failure. (Lainscak, M., et al., 2016)

Creative Biolabs provides professional pharmacokinetic services for efficacy evaluation of drug research and development thus to deal with data reproducibility crisis which is a big obstacle for drug research and development and may lead to failure and high risk of investment. With our professional PK studies, we can drive forward and speed up your drug discovery and development process.

Creative Biolabs offers comprehensive pharmacokinetic services, including but not limited to the following:

Pharmacokinetic Assays

Pharmacokinetic (PK) studies are of great significance in the development of new drugs. It is helpful to understand both the beneficial and harmful effects of drug candidates and guide drug development experiments and clinical trials. Pharmacokinetic assays are an essential component of the drug development process, and the data obtained is used to help select dosage for preclinical and clinical studies. In PK assays, the applied assay method should be well characterized and fully validated, in order to obtain reliable results. With extensive knowledge of drug discovery and development, we apply our expertise in a variety of pharmacokinetic assays to support PK studies, and provide high-quality results to meet our clients’ needs.

Pharmacokinetic Models

Pharmacokinetic modeling is a mathematical modeling technique to predict the absorption, distribution, metabolism and excretion (ADME) of a drug. PK models are generated to elucidate the transformations that a drug undergoes in an organism and the rules that determine this fate. Pharmacokinetic model is the central piece of model-based drug development. It is performed by noncompartmental or compartmental methods. We provide both non-compartmental and compartmental methods for PK modeling. We also offer services to transform published non-compartment model PK parameters into compartment model PK parameters.

Pharmacokinetic Disease Models

With extensive experience and advanced technology, we can provide both standard and customized pharmacokinetic disease models in the most high-quality and cost-effective way for worldwide clients. Working in the field of PK studies for many years, we have developed a series of physiological based pharmacokinetic disease models to help our clients clarify disease-related PK parameter changes, which is very important for predicting the profound impacts of diseases-related pathophysiological changes on the pharmacokinetic behavior of drugs.

Creative Biolabs has a dedicated assay development team that will work closely with you to design customized assays. Our service will meet your specific needs fast at extremely competitive prices. If you need more information, please feel free to contact us at anytime. We look forward to working with you to help your drug research and development project succeed.

Reference

1. Lainscak, M., et al., 2016. Pharmacokinetics and pharmacodynamics of cardiovascular drugs in chronic heart failure. International journal of cardiology, 224, pp. 191-198.