In Vivo Functional Analysis

Creative Biolabs provides in vivo functional analysis for target validation of drug discovery process thus to deal with data reproducibility crisis which is a big obstacle for drug research and development and may lead to failure and high risk of investment. In vivo functional analysis is necessary to evaluate the relevance of a particular target for the disease in appropriate animal models using suitable biological tools. Multiple preclinical disease models including non-human primate disease models are available at Creative Biolabs to mimic the systemic implications of disease and can provide early in vivo key data for drug targets.

Creative Biolabs offers comprehensive in vivo functional analysis, including but not limited to the following:

Animal Models

Animal experiments depend on the relative animal models. The development of animal models plays important roles in every aspect of clinical research. In vivo target validation with predictive animal models is a crucial part of the drug development process. The ability to perform in vivo target validation provides higher value information than in vitro validation to understand the role of a particular target in the disease process, multiple genes cooperation in the same pathway, as well as the role of the pathway in the disease. This information is vitally critical to the drug discovery process. Animal models similar to human pathophysiology are also invaluable for the characterization of the mechanism of action, pharmacokinetics, pharmacodynamics, and safety of future therapies.

With professional experts and cutting-edge technical platforms, we provide the best and most comprehensive popular animal models and disease models to provide key data for drug targets. The species of our animal models cover rats, mice, rabbits, dogs and non-human primates. We also offer full service for design and creation of customized models to suit all your specific requirements.

Biological Tools

Monoclonal antibodies and recombinant proteins are important biologic tools for in vivo target validation. Antagonistic or agonistic monoclonal antibodies could be used for target validation according to different targets. Depending on the specific target or pathway, recombinant proteins could also have activating or inactivating properties. Although the use of biological products is a valuable method for in vivo target validation, this process is sometimes hindered by the development of immunogenicity against biologics, and lacks of existing tools of high quality and specificity to the target of interest.

Genetic approaches are becoming complementary strategies for evaluating targets difficult for using biological tools. There has been a growing collection of genetic approaches include but are not limited to adeno-associated virus (AAV), lentivirus, RNA interference (RNAi), transcription activator-like effector nuclease (TALEN), meganuclease, and CRISPR-Cas9 technologies. We provide professional in vivo functional analysis using a comprehensive suite of biological tools for target validation.

Creative Biolabs has a dedicated assay development team that will work closely with you to design customized assays. Our service will meet your specific needs fast at extremely competitive prices. If you need more information, please feel free to contact us at anytime. We look forward to working with you to help your drug research and development project succeed.